Bovine trichomoniasis (BT) is a venereal disease that causes substantial economic losses to the cattle industry worldwide. BT has been endemic in the United States since the 1930s. It is a sexually transmitted disease of cattle infecting the reproductive tract of cows, resulting in pyometra and possible mid- to late-term abortions. BT is caused by Tritrichomonas foetus, a type of protozoan extracellular parasite. T. foetus primarily inhabit the genital tracts of the cows, where they overcome the mucus barrier and parasitize mucosa by contact-dependent or contact-independent cytotoxicity.